Diagnostic accuracy of the second generation dual-source dual-energy CT myocardial perfusion imaging in patients with suspicious myocardial infarction

Objectives To evaluate the diagnostic accuracy of the second generation dual-source dual-energy CT myocardial perfusion imaging in patients with suspicious myocardial infarction. Methods Fifty-six patients underwent dual-source dual-energy myocardial perfusion imaging, of which forty patients had follow-up results [confirmed by catheter coronary angiography, cardiac troponin I elevation and Electrocardiogram (ECG) changes and evolution of acute myocardial infarction] within 30 days.Catheter coronary angiography and clinical data served as the standard of references.The sensitivity, specificity and positive and negative predictive values of the second generation dual-source dual-energy CT myocardial perfusion in the detection of myocardial infarction were evaluated.The coronary image quality and radiation dose were evaluated. Results Diagnostic accuracy: the sensitivity, specificity and positive and negative predictive values were 95.0%, 97.0%, 86.4% and 98.9%, respectively.Coronary image quality: one patient with non-diagnostic images was due to motion artifacts occurred at the right coronary artery and left circumflex artery; another patient′s vessels were unassessable due to the motion artifacts induced by high heart rate variability; the other patients′ image quality were good.Radiation dose: the average effective radiation dose was (6.1±1.5)mSv. Conclusion One-step dual-source dual-energy CT myocardial perfusion scan combined with coronary CTA provide high diagnostic accuracy for detecting myocardial infarction with lower radiation exposure in patients with suspicious myocardial infarction. Key words: Tomography, x-ray computed; Myocardial perfusion imaging; Myocardial infarction; Diagnosis