H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Michael Seiler,Akihide Yoshimi,Rachel Darman,Betty Chan,Gregg F. Keaney,Mark G. Thomas,Anant A. Agrawal,Benjamin Caleb,Alfredo Csibi,Eckley Sean,Peter Fekkes,Craig Karr,Virginia M. Klimek,George Lai,Linda Lee,P.V. Kumar,Stanley Lee,Xiang Liu,Crystal Mackenzie,Carol Meeske,Yoshiharu Mizui,Eric Padron,Eunice Park,Ermira Pazolli,Shouyong Peng,Sudeep Prajapati,Justin Taylor,Teng Teng,John Wang,Markus Warmuth,Huilan Yao,Lihua Yu,Ping Zhu,Omar Abdel Wahab,P.G.R. Smith,Silvia Buonamici

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

2018

The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding spliceosome components.

Keywords:

Lethality
Virology
Spliceosome
Small molecule
Mutant
Gene
RNA splicing
Molecular biology
Medicine
Cell biology
tumor cells

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