The zika virus individual participant data consortium: A global initiative to estimate the effects of exposure to zika virus during pregnancy on adverse fetal, infant, and child health outcomes
2020
This commentary describes the creation of the Zika Virus Individual Participant Data
Consortium, a global collaboration to address outstanding questions in Zika virus (ZIKV) epidemiology
through conducting an individual participant data meta-analysis (IPD-MA). The aims of the IPD-MA
are to (1) estimate the absolute and relative risks of miscarriage, fetal loss, and short- and long-term
sequelae of fetal exposure; (2) identify and quantify the relative importance of different sources of
heterogeneity (e.g., immune profiles, concurrent flavivirus infection) for the risk of adverse fetal,
infant, and child outcomes among infants exposed to ZIKV in utero; and (3) develop and validate a
prognostic model for the early identification of high-risk pregnancies and inform communication
between health care providers and their patients and public health interventions (e.g., vector control
strategies, antenatal care, and family planning programs). By leveraging data from a diversity of
populations across the world, the IPD-MA will provide a more precise estimate of the risk of adverse
ZIKV-related outcomes within clinically relevant subgroups and a quantitative assessment of the
generalizability of these estimates across populations and settings. The ZIKV IPD Consortium effort
is indicative of the growing recognition that data sharing is a central component of global health
security and outbreak response.
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