The Study for the Relation Between the Serum Concentration of Lamotrigine and its Effect

Objective:To explore the the reciprocity of lamotrigine(LTG),valproate(VPA),carbamazepine(CBZ) and other anti-epileptic drugs and analyze the relativity between blood concentration of LTG and clinical response.Methods: All cases were divided into 5 groups,then ANOVA,χ2 and relativity analysis were employed.Results: VPA combination enhanced LTG blood concentration,CBZ combination reduced LTG blood concentration.Obvious relativity between blood concentration of LTG and LTG maintaining dose was observed in the cases of LTG monotherapy(r=0.889,P0.05).Clinical response of 5 groups were obviously different(χ2=22.508,P0.05).Conclusions: Serum concentration and maintaining dose of LTG are effected by many factors,such as,other anti-epilepsy drugs and individual difference.Therefore TDM is an essential tool to control seizure.