Treatment of migraine with drugs related to 5-hydroxytryptamine

The 5-hydroxytryptamine (5-HT) antagonist methysergide was introduced in the prophylaxis of migraine in 1959 [1] and later proved to be quite effective [2]. Ergotamine, one of the traditional drugs used in the treatment of migraine attacks, was later found to act on 5-HT receptors [3]. Recently GR43175, a 5-HT1-like receptor agonist, has been introduced as a new treatment for migraine attacks [4].