Magnesium Sulfate and Betamethasone Reduce NUR77 Expression in a Preterm Labor Mouse Model

Abstract : Women in preterm labor are commonly treated with magnesium sulfate (MgSO4) and betamethasone (BMTZ) to reduce complications of prematurity including neurologic injury. MgSO4, however, prevents cerebral palsy in only 1 in 40 women who receive it. Understanding the cellular responses to MgSO4/BMTZ could allow for more effective treatments. Nur77 is a nuclear receptor implicated in apoptosis and immune responses- processes that occur in neuroinflammation. Our objective was to investigate if Nur77 is increased in the setting of inflammation-induced preterm labor and determine the impact of MgSO4 and BMTZ treatments.