Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Ruisheng Song,Wei Peng,Yan Zhang,Fengxiang Lv,Hong-Kun Wu,Jiaojiao Guo,Yongxing Cao,Yanbin Pi,Xin Zhang,Li Jin,Mao Zhang,Peng Jiang,Fenghua Liu,Shaoshuai Meng,Xiuqin Zhang,Ping Jiang,Chun-Mei Cao,Rui-Ping Xiao

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

2013

Ruisheng Song
Wei Peng
Yan Zhang
Fengxiang Lv
Hong-Kun Wu
Jiaojiao Guo
Yongxing Cao
Yanbin Pi
Xin Zhang
Li Jin
Mao Zhang
Peng Jiang
Fenghua Liu
Shaoshuai Meng
Xiuqin Zhang
Ping Jiang
Chun-Mei Cao
Rui-Ping Xiao

MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues.

Keywords:

Insulin resistance
Ubiquitin ligase
IRS1
Insulin-like growth factor 1 receptor
Downregulation and upregulation
Insulin receptor
Metabolic syndrome
Endocrinology
Biology
Internal medicine
Type 2 diabetes
Insulin

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