Bevacizumab, erlotinib, and imatinib in the treatment of patients with advanced renal cell carcinoma: Update of a multicenter phase II trial

4594 Background: Most patients with clear cell RCC have loss of von-Hippel-Lindau (VHL) gene function, ultimately leading to overexpression of VEGF, transforming growth factor (TGF-α), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF). In this phase II trial, we evaluate the combination blockade of VEGF, and the EGF and PDGF receptors as treatment for metastatic RCC. Methods: Eligibility: metastatic clear cell RCC; 0–2 previous systemic regimens; ECOG PS 0–1; no previous anti-angiogenesis or EGF receptor inhibitor therapy; no active CNS metastases; adequate organ function; no history of thromboembolic disease; informed consent. All patients received bevacizumab 10 mg/kg IV q 2 wks, erlotinib 150 mg PO daily, and imatinib 400 mg PO daily. Patients were evaluated for response after 8 weeks; treatment continued until tumor progression. Results: 92 patients entered this trial between 6/04 and 4/05. Pertinent clinical characteristics: no previous systemic treatment, 71%; Motzer prognosti...