Preparation and in Vitro Release of Vinblastin-loaded Poly (lacticacid) Nanoparticle

Objective:To prepare the Vinblastin-loaded poly(lactic acid) nanoparticles (VLB-PLA-NPs) and to investigate its in vitro release.Methods:An emulsion solvent evaporation technique was used to prepare the vinblastin-loaded poly (lactic acid) nanoparticles (VLB-PLA-NPs).The Entrapment Efficiency and in vitro release was chosen as indexes for the VLB-PLA-NPs formulation.Results:The average diameter of VLB-PLA-NPs was (65±3.03) nm, and the drug loading and the envelope ratio of the nanopaticles were 3.323± 0.01μg/mg and (99.68±0.30)%.The drug release degree of VLB-PLA-NPs was about 30%, which decreased in 24 hour and the total drug release degree in 20 days is 97%.Conclusion:The preparation method is reliable and simple.The nanoparticles possessed good physical performance and sustained release character in vitro.