TheMalmoPolymorphism ofCoagulation FactorIX, An Immunologic Polymorphism DuetoDimorphism ofResidue 148ThatIsinLinkage Disequilibrium withTwo OtherF.IXPolymorphisms

Summary A mouse monoclonal antibody (MAB9.9) tocoagulation factor IX(F.IX) detects a polymorphism inthe plasma ofnormal people. Itsepitope hasbeennarrowed downto<6aminoacids intheactivation peptide oftheX-linked F.IXprotein. Theactivation peptide contains a dimorphism-Thr:Ala-at position 148of theprotein. Using synthetic oligonucleotides,