Effect of α-tocopherol on redox-status alterations and paraneoplastic disorders of erythrocytes

Have been investigated erythrocytes' membrane resistance (ER), deformability (ED) and electronic-paramagnetic signals of blood and liver tissue of white rats (weight range 220-250 g.) during Walker carcinoma growth before and after treatment with atocopherol with the use of methods: spectrophotometry, filtration-computed photometry and electronic-paramagnetic resonance (EPR). Investigations have shown paraneoplastic alterations of redox-potential of blood and liver tissue, disorders of mitochondrial respiration and activity of antioxidant processes, exaggerated lipid peroxidation (POL), reduced ER and ED, altered processes of detoxication. Important role of redox-potential disturbances in paraneoplastic disorders of erythrocytes membrane is confirmed by positive influence of antioxidant and membrane-stabilizing therapy. After treatment with α-tocopherol the above-mentioned disturbances vividly were reduced. owadays, treatment of oncological patients involves surgical, chemical and radiotherapies. However, surgical intervention even carried out technically perfectly and other manipulations in most cases are hopeless and patients’ life span is still limited and prognosis is poor. Presumably, the reason is ignorance of those paraneoplastic disorders of “intact” organs and tissues that always accompany malignant tumor growth. They are first “messengers” of grave and cruel disease, because paraneoplastic disorders are manifested long before the malignant growth reveals itself. Paraneoplastic processes aggravate course of prime disease and often play the leading role in the lethal outcome [1.2.3.4.5]. Thus, investigation of disorders of "intact" organs (organs that are not directly affected or involved in the malignant growth) and their pathogenetic correction, alongside with existing methods of treatment, considerably would increase the lifespan of oncological patients. Malignant growth involves entirely the organism, affects organs and tissues directly or indirectly. Among “victims” are erythrocytes. They are very labile, fragile and no wonder that immediately reflect any deviations occurred in organism. Erythrocytes functional state in turn determines intensity of microcirculation and both are responsible for generalized hypoxia accompanying malignant tumor growth. As far as changes in redoxpotential of cells ant tissues underlie almost all pathological processes, in an attempt to state mechanisms of erythrocytes’ membrane paraneoplastic disorders we decided to investigate processes of oxidation and reduction in case of malignant tumor growth, establish their role in pathogenesis of paraneoplastic disorders and elaborate appropriate methods of their correction. Proceeding from the aforesaid, the purpose of our research was to study erythrocytes’ membrane resistance and deformability, and electronic-paramagnetic signals of blood and liver tissue of laboratory rats in dynamics of experimental malignant tumor growth.