Clinical analysis for long protocol controlled ovarian stimulation of in vitro fertilization and embryo transfer

Objective To analyze the clinical effect of GnRH-a 1.25 mg long protocol for controlled ovarian stimulation on in vitro fertilization and embryo transfer(IVF-ET).Methods Clinical data of 137 cycles of GnRH-a 1.25 mg long protocol for controlled ovarian stimulation on IVF-ET in our reproductive center were analyzed retrospectively,and the effect of IVF in pregnancy group and non-pregnancy group was compared.According to the number of retrieved oocyte,the 137 cycles were divided into three groups: group 1(retrieved oocyte number ≤8),group 2(9≤ retrieve oocyte number ≤17) and group 3(retrieved oocyte number ≥18),a comparative analysis about endocrine changes in course of ovarian stimulation and clinical outcomes among the three groups was carried out.Results The retrieved oocytes numbers between pregnancy group and non-pregnancy group had no significant difference(P0.05),while the normal fertilization rate was statistically different(P0.05).Patients in group 3 were young and had the highest ovarian response and frozen embryos rate(P0.05).However,the pregnancy rate of the single-transplant cycle among the three groups had no significantly difference(P0.05).With the retrieved oocytes numbers increasing,the risk of ovarian stimulation syndrome was significantly increased(P0.05).Conclusion Satisfactory clinical effects can be achieved from GnRH-a 1.25 mg long protocol for controlled ovarian stimulation cycles in conditions of normal fertilization rate.