Acylphenols and dimeric acylphenols from Myristica maxima Warb.

Abstract Giganteone E ( 1 ), a new dimeric acylphenol was isolated as a minor constituent from the bark of Myristica maxima Warb. The structure of 1 was established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Malabaricones A–C ( 2 – 4 ), giganteones A and C ( 5 and 6 ), maingayones A and B ( 7 and 8 ), maingayic acid B ( 9 ) and β -sitosteryl oleate ( 10 ) were also characterized in this plant for the first time. Compound 10 was identified for the first time in the Myristicaceae. Compounds 2 and 5 were active against human prostate cancer cell-lines, thus making this the first report on the prostate cancer inhibiting potential of acylphenols and dimeric acylphenols. Compounds 1, 4 , 5, 7 and 8 exhibited potent DPPH free radical scavenging activity. This is the first report on their free radical scavenging capacity.