In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

M. Verstraete,Annelies Debucquoy,Annelies Gonnissen,Rüveyda Dok,Sofie Isebaert,Ellen Devos,William H. McBride,Karin Haustermans

In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

2015

M. Verstraete
Annelies Debucquoy
Annelies Gonnissen
Rüveyda Dok
Sofie Isebaert
Ellen Devos
William H. McBride
Karin Haustermans

Background We examined the anti-tumor effect and radiosensitizing potential of a small molecule inhibitor of fibroblast growth factor receptor (FGFR) in colorectal cancer (CRC) in vitro and in vivo.

Keywords:

Cancer research
Medicine
Pathology
Fibroblast growth factor receptor
Colorectal cancer
Cancer
In vivo
Cell growth
In vitro
Caco-2
Signal transduction
Cell cycle
FGFR Inhibition
Apoptosis
Cell culture

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