Prostatin Transüretral Rezeksiyonu Sirasindaki Kan Kaybinin Azaltilmasinda Finasterid'in Rolü

In this prospective, randomized study, we aimed to evaluate the efficacy of presurgical finasteride therapy in decreasing perioperative bleeding during transurethral resection of the prostate (TUR-P). A total of 60 patients scheduled to undergo elective transurethral prostate resection were included in the to study. Randomly selected 30 patients received 5 mg finasteride for 2 weeks before surgery while another 30 did not receive any pretreatment. Blood hemoglobin was measured before and after the surgery. The volume and hemoglobin concen- tration of irrigation fluid, resected prostate weight and duration of resection were recorded. No statisticaliy significant differences were found between the two groups for patient age, PSA level, resected tissue volume and duration of resection. The mean hemoglobin concen- tration in the irrigation fluid was significantly lower in the finasteride group, than the control group (p=0.017). When the blood loss per gram of resected prostate tissue calculated, the mean difference was more significant (p=0.005). This study shows that preoperative finas- teride administration for 2 weeks decreases bleeding in patients undergoing transurethral prostate resection.