Neoadjuvant Chemotherapy: Osaka University Osteosarcoma (OOS) Regimen

Objective: The purpose of this study is to evaluate the efficacy of a four-drug regimen neoadjuvant chemotherapy for osteosarcoma with doxorubicin, cisplatin, methotrexate, and ifosfamide for patients ≤40 years of age with nonmetastatic osteosarcoma of the extremity.