Height Velocity in Short Children During Second and Third Years of Growth Hormone (GH) Treatment: Data From the National Cooperative Growth Study (NCGS)

INTRODUCTION Although GH has been used to treat short stature in GHD and other conditions for over • 40 years, criteria for satisfactorily defining targets for GH responsiveness for multiple years of treatment have never been developed. The range of GH response is large; differences can be attributed to diagnosis, age, GH dose, • parental height, compliance, intercurrent illness, other (endocrine) therapies, and still poorly defined molecular and biochemical factors. We recently published HV targets from NCGS for first-year GH responses in short children. • 1