Overestimation of tumor mutational burden (TMB) using algorithms compared to germline subtraction.

Kaushal Parikh,Robert Huether,Kevin P. White,Derick Hoskinson,Haidong Dong,Alex A. Adjei,Aaron S. Mansfield

Overestimation of tumor mutational burden (TMB) using algorithms compared to germline subtraction.

2019

Kaushal Parikh
Robert Huether
Kevin P. White
Derick Hoskinson
Haidong Dong
Alex A. Adjei
Aaron S. Mansfield

2621Background: TMB is an emerging predictor of survival with immunotherapy. TMB is determined by taking the difference between somatic and germline datasets when tumor-normal pairs are available. ...

Keywords:

Subtraction
Germline
Pathology
Medicine
Bioinformatics
Immunotherapy
Somatic cell
Internal medicine
Oncology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations