Urachal adenocarcinoma of bladder: clinical analysis of six cases

The clinical and pathological data of 6 patients with urahcal adenocar, cinoma of the bladder admitted in Beijing Luhe Hospital from 1996 to 2016 were analyzed and relevant literature was reviewed. Urachal carcinoma accounted for 0.66% of the bladder cancers admitted at the same period (6/906) and 6/16 of the bladder adenocarcinomas. Painless hematuria was the most common symptom. One patient had extensive metastasis as shown in biopsy and died 6 month after the diagnosis. Two patients underwent partial excision of bladder with no tumor recurrence. One patient underwent partial cystectomy followed by chemotherapy and radiotherapy, recurrence occurred one year later and he then received radical cystectomy. Another 2 patients underwent laparoscopic cystectomy and en bloc resection of umbilical ligament and umbilicus, and no recurrence was found in the follow-up for 6 years and 15 months, respectively. Pathological and immunohistochemistry are essential for the diagnosis of urachal adenocarcinoma. As it is not sensitive to radiotherapy or chemotherapy, surgery is the preferred treatment for patients with early stage diseases. Individual anticancer therapy may be the trend of treatment. Key words: Urinary bladder neoplasms; Adenocarcinoma; Adenocarcinoma, urachus