The target cells of IL-33 effects and its roles in parasite infection immunity

IL-33 is a novel member of IL-1 cytokine family and mediates its biological effects via the ST2 receptor,which is selectively expressed on Th2 cells and mast cells.IL-33 leads to activation of T-helper type 2 cells,mast cells,dendritic cells,eosinophils,and basophils,ultimately leading to increased expression of cytokines.Cytokine-mediated immunity plays a crucial role in the pathogenesis of various inflammation and parasitic diseases.So here we reviewed the target cells of the biological effects of IL-33 in parasitic infection. Key words: IL-33 ;  Target cells;  Parasite infection