Suplementação em iodo durante a gravidez - impacto no neurodesenvolvimento infantil? Iodine supplementation in pregnancy - impact on infant neurodevelopment?

Objective: Review the available evidence of iodine supplementation impact on infant neurodevelopment during pregnancy. Methods: Research of meta-analysis (MA), systematic reviews (SR), original studies (OS), and clinical guidance standards (NOC), in English and Portuguese, published between 01/2003 and 05/2013 in Pubmed/Medline, sites of evidence-based medicine and in Portuguese Medical Journals Index, using the MeSH terms: iodine; pregnancy; child; neurodevelopment. For the assessment of levels of evidence (NE) and assignment of forces recommendation (FR) the SORT (Strength of Re - commendation Taxonomy) scale of American Family Physician was used. Results: Nineteen articles were found, of which 6 were selected: 3 OS, 1 SR and 1 NOC. Two OS (both NE 1) reported no statistically significant relationship between iodine supplementation during pregnancy and child neurodevelopment. The SR (NE 1) and one OS (NE 2) reported an association between iodine supplementation during pregnancy and neuroco - gnitive performance improvement in children. The WHO/UNICEF NOC (FR A) recommends supplementation with 250 g/day of iodine to all pregnant women. Conclusion: The available evidence has shown that iodine supplementation during pregnancy has benefits in infant brain development (Strength of recommendation B). Further studies are necessary to assess safety and long-term effectiveness before this measure's systematic implementation of this measure.