Recent research on liquisolid technology for solubility enhancement- A review

Liquisolid system is a novel and promising approach to enhance aqueous solubility, dissolution rate as well as bioavailability of water insoluble solid drugs or liquid lipophilic drugs by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents, into dry, non-adherent, free flowing and compressible powder mixtures by simple blending with selected carriers and coating materials. This technology is based on a new mathematical model proposed by Spireas et al. The three main proposed mechanisms by which bioavailability of drug is increased that are increased surface area of drug, increase aqueous solubility of drug and improved wettability of the drug.