Fungal burden and raised intracranial pressure are independently associated with visual loss in HIV-associated cryptococcal meningitis

Amongst 472 patients with HIV-associated cryptococcal meningitis, 16% had severe visual loss at presentation, of whom 46% of 4-week survivors remained severely impaired. Baseline CSF opening pressure ≥40 cmH20 (aOR 2.56, 95% CI 1.36-4.83, p=0.02) and fungal burden >6.0 log10Colonies/ml (aOR 3.01, 95%CI 1.58-5.7, p= 0.003) were independently associated with severe visual loss.