Drug-Metabolizing Ability and Inducibility of Chromosomal Aberrations and Sister Chromatid Exchanges in LEC Rats Exposed to Cyclophosphamide

The LEC rat strain is a new mutant characterized by the spontaneous development of hepatitis with severe jaundice about 4 months of age [1, 2]. Genetic analysis demonstrated that the disease has an autosomal recessive mode of inheritance, being ruled by a single gene named hts [3]. Although about 30% of rats die of fulminant hepatitis within 1 week after the onset of jaundice, the remaining animals survive with chronic hepatitis for more than 1 year and develop liver cancer [4].