Associations of Serum Adipokines with Subclinical Interstitial Lung Disease Among Community-Dwelling Adults: the MESA study

2019 
Abstract Background Adipokines have inflammatory and fibrotic properties that may be critical in interstitial lung disease (ILD). We examined associations of serum adipokine levels with computed tomography (CT)-based measures of subclinical ILD and lung function among community-dwelling adults. Methods A subset of the original Multi-Ethnic Study of Atherosclerosis cohort (n=1,968) had adiponectin, leptin, and resistin measured during follow-up visits (2002-2005). We used regression models to examine associations of adiponectin, leptin, and resistin levels with 1) high attenuation areas (HAA) from CT scans (2004-2005, n=1,144), 2) interstitial lung abnormalities (ILA) from CT scans (2010-2012, n=872), and 3) forced vital capacity (FVC) from spirometry (2004-2006, n=1,446). We used ( − 1 H A A 2 ) , which we denoted with H, to model HAA as our outcome to meet model assumptions. Results Higher adiponectin was associated with lower HAA on CT among adults with a body mass index (BMI) ≥25 kg/m2 (P for BMI interaction=0.07). Leptin was more strongly associated with ILA among never smokers compared to ever smokers (P for smoking interaction=0.004). For every 1-SD increment of log-transformed leptin, the % predicted FVC was 3.8% lower (95% CI: −5.0, −2.5). Higher serum resistin levels were associated with greater HAA on CT in a fully-adjusted model. For every 1-standard deviation (SD) increment of log-transformed resistin there was an increase in H of 14.8 (95% CI: 3.4, 26.3). Conclusions Higher adiponectin levels were associated with lower HAA on CT among adults with a higher BMI. Higher leptin and resistin levels were associated with lower FVC and greater HAA, respectively.
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