Droplet evaporation residue indicating SARS-COV-2 survivability on surfaces.

SARS-CoV-2 has a long survive time on different surfaces and can remain viable under different environments as reported in recent studies. However, it is still unclear how the viruses survive for such a long time and why their survivability varies between different surfaces. To address these questions, we conducted systematic experiments investigating the evaporation of droplets produced by a nebulizer and human-exhaled gas on different surfaces. We found that these droplets do not disappear immediately with evaporation, but instead shrink to a size of a few micrometers (referred to as residues) which can stay on a surface for more than 24 hours. The evaporation characteristics of these residues change significantly with surface types. Specifically, the surfaces with high thermal conductivity like copper do not leave any resolvable residues, while stainless steel, plastic and glass surfaces form residues that remain stable for extended durations. Lowering humidity can significantly suppress the formation of residues. Such trends are well correlated with SARS-CoV-2 survivability measurements in the literature. Our results suggest that these microscale residues can potentially insulate the virus against environmental changes, allowing them to survive inhospitable environments and remain infectious for prolonged durations after deposition. Our findings are also applicable for other viruses that are transmitted through respiratory droplets (e.g., SARS-CoV-1, flu viruses, etc.), and can lead to practical guidelines for disinfecting surfaces of different types and other prevention measures (e.g., humidity control) for limiting virus infection.