A controlled trial ofcarbenoxolone sodium capsules inthetreatment ofduodenal ulcer

Carbenoxolone sodiumisan effective agent promoting thehealing ofchronic gastric ulcers (Doll, Hill, Hutton, andUnderwood, 1962; Doll, Hill, andHutton, 1965;Horwich andGalloway, 1965;Turpie andThomson, 1965). Thedrugis readily absorbed fromthestomach andislargely excreted inbile(Iveson, Parke, andWilliams, 1966). Itisbelieved tohavealocal effect onthe gastric mucosathrough its strong affinity formucus, andthere isindirect evidence thatitmayenhance mucussecretion (Goodier, Horwich, andGalloway, 1967; Dean,1968). Whenadministered intablet formithasnodemonstrable effect onthecourse of duodenal ulceration. Preliminary radiological experiments witha