ASSESSMENT OF THE IMMUNE RESPONSE IN KIDNEY TRANSPLANT PATIENTS

Chapter 1: Introduction Literature Review 1.1 Historical overview 1.2 Renal transplantation 1.3 Transplantation immunology 1.3.1 The major histocompatibility complex 1.3.2 T lymphocyte alloantigen recognition 1.3.3 T lymphocyte activation 1.4 Immunosuppressive drugs 1.4.1 Calcineurin inhibitors 1.4.2 mTOR inhibitors (mammalian "Targets of rapamycin") 1.4.3 Mode of action 1.5 Complications of immunosuppressive therapy 1.5.1 Rejection 1.5.1.1 Hyperacute rejection 1.5.1.2 Acute rejection 1.5.1.3 Chronic rejection 1.5.2 Infection 1.5.3 Malignancy 1.6 A TP bioluminescence assay 1.6.1 Adenosine Triphosphate (ATP) 1.6.2 Bioluminescence