Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome.
2020
We report on patients with STAT3 loss-of-function (LOF) mutations who developed lupus-like autoimmunity. Immune dysregulation seen in STAT3 LOF patients suggests a susceptibility to systemic autoimmunity with important implications in monitoring and management of these patients.
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