An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma

Bo Xu,Rui Ma,Luke Russell,Ji Young Yoo,Jianfeng Han,Hanwei Cui,Ping Yi,Jianying Zhang,Hiroshi Nakashima,Hongsheng Dai,E. Antonio Chiocca,Balveen Kaur,Michael A. Caligiuri,Jianhua Yu

An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma

2018

Bo Xu
Rui Ma
Luke Russell
Ji Young Yoo
Jianfeng Han
Hanwei Cui
Ping Yi
Jianying Zhang
Hiroshi Nakashima
Hongsheng Dai
E. Antonio Chiocca
Balveen Kaur
Michael A. Caligiuri
Jianhua Yu

An engineered oncolytic herpesvirus shows enhanced intratumoral spread, resistance to NK cell clearance and improved efficacy against brain cancer in mice.

Keywords:

Glioblastoma
Cadherin
Molecular biology
Oncolytic virus
Cancer
Cancer research
Biology
Herpes simplex virus
Cell
Virus
Viral entry
Virotherapy
Innate immune system
cell killing

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