Aminodiol HIV protease inhibitors. 2. 1,1-Dimethyl-2-hydroxyethyl carbamate derivatives with enhanced potency

Abstract A series of BOC-modified analogs of the aminodiol HIV protease inhibitor BMS-182193 (1) was prepared and tested for inhibitory activity against the enzyme and the virus in cell culture. The hydroxymodified analogs, 5 and 20 , showed enhanced potency against the protease and 5 was more active than 1 against the virus in cell culture.