Are young breast cancer patients' clinico-pathological characteristic different when comparing populations from developing countries? Analysis of two cohorts of patients from Romania and Mexico.

e13572Background: Breast cancer (BC) is the most common malignancy in women with 6.6% of cases diagnosed in young women below the age of 40. Although there are significant similarities in demographic and clinico-pathological characteristic between geographical areas, the striking difference is in peak age for young populations. Objetive:Comparison of two young breast cancer(YBC) patients (pts) cohorts candidates for BRCA gene testing of two Developing Countries Methods: In this retrospective study, we analyzed 2 cohorts of 70 YBC pts candidates for BRCA gene testing treated at COEI in Mexico between 2013 to 2015 and IOCN from Romania between 2015 to 2016.Patient demographic and clinico-pathological information was recorded, and included: age at diagnosis, laterality presentation, clinical stage, Scarff-Bloom-Ricardson (SBR) grading, hormone receptor (HR), HER2neu and Ki 67% status Results: The analysis of these cohorts revealed clinical stage to be statistically significant different,(p = 0.0084), the Rom...