Clinical Efficacy of Yupingfeng Capsule in Treatment of Allergic Rhinitis and Its Safety Evaluation

Objective: To investigate the clinical efficacy of Yupingfeng capsules in the treatment of allergic rhinitis and its safety evaluation and to provide a reference for its clinical diagnosis and treatment. Methods: 220 cases of allergic rhinitis were randomly divided into two groups according to the random number table:control group(n = 102) and treatment group(n = 118). The control group used left cetirizine hydrochloride tablets combined with budesonide nasal spray and the treatment group used Yupingfeng capsule orally. Two groups were both treated for a course of a month. Results:The total effective rate of the treatment group after treatment(87. 29%) was significantly higher than that of control group(68.63%) and there was a significant difference(P 0.05). After treatment,turbinate volume score(1.79 ±0.36) in the treatment group was significantly lower than that before(2. 51 ± 0. 48) and there was a significant difference( P 0. 05). After treatment,turbinate volume score(1. 79 ± 0. 36) in the treatment group was significantly lower than that of the control group(2. 13 ± 0. 38) and there was a significant difference( P 0. 05). IL- 4(109. 53 ± 38. 64 pg /mL)and IgE(139. 07 ± 50. 38 IU /mL) were significantly lower than IL- 4(147. 47 ± 47. 29 pg /mL) and IgE(178. 53 ±53. 08 IU /mL) of the control group after treatment and there was a significant difference(P 0. 05). After treatment,IL- 12(67. 84 ± 12. 36 pg /mL) was significantly higher than that of control group(46. 81 ± 14. 94 pg /mL) and there was a significant difference( P 0. 05). Conclusion: Treatment of allergic rhinitis with Yupingfeng capsule has significant clinical effect. It can significantly improve patients' serum markers and secure and has important clinical research value. It should be widely applied.