Progress in comprehensive treatment of pulmonary large cell neuroendocrine carcinoma

Large cell neuroendocrine carcinoma is not very common, and it has a high degree of malignancy and invasion, outcome is also poor. Even LCLC is defined as non-small cell lung cancer, its biological and clinical characteristics, prognostic factors are similar to small cell lung cancer. The treatment for LCLC is still controversial. The research progress on comprehensive treatment of lung large cell neuroendocrine carcinoma was reviewed. Key words: Lung large cell neuroendocrine carcinoma/combined modality therapy; Progression