Preoperative Chemotherapy for the Treatment of Osteosarcoma

At present, preoperative chemotherapy preceding limb-salvage surgery, is indispensable therapy for patients with osteosarcoma, in addition to being the most important prognostic factor. The aims of preoperative chemotherapy are (1) to control micrometastasis, (2) to control the primary tumor, and (3) to assess the effectiveness of the drugs used by grading of primary tumor necrosis.