In vitro anti-human immunodeficiency virus activity of 2',3'-dideoxynucleosides and their effect on clonal growth of hemopoietic cells from human bone marrow.

Seven 2',3'-dideoxynucleosides synthesized by substitution of nucleosides using nucleoside deoxyriboxyltransferase from Lactobacillus leichmanii were tested for their anti-human immunodeficiency virus (HIV) activity. Two of them, including 2,6-diaminopurine-2',3'-dideoxyriboside (DAPDDR) and 6-chlorpurine-2'-3'-dideoxyriboside (CPDDR) demonstrated high antiviral activity against several strains of HIV-1 and one stain of HIV-2