Molecular determinants of drug response in TNBC cell lines

Nathan M. Merrill,Eric J. Lachacz,Nathalie Vandecan,Peter J. Ulintz,Liwei Bao,John P. Lloyd,Joel A. Yates,Aki Morikawa,Sofia D. Merajver,Matthew B. Soellner

Molecular determinants of drug response in TNBC cell lines

2019

Nathan M. Merrill
Eric J. Lachacz
Nathalie Vandecan
Peter J. Ulintz
Liwei Bao
John P. Lloyd
Joel A. Yates
Aki Morikawa
Sofia D. Merajver
Matthew B. Soellner

Purpose There is a need for biomarkers of drug efficacy for targeted therapies in triple-negative breast cancer (TNBC). As a step toward this, we identify multi-omic molecular determinants of anti-TNBC efficacy in cell lines for a panel of oncology drugs.

Keywords:

Breast cancer
Cancer research
Drug
Efficacy
Cell culture
Oncology drugs
Triple-negative breast cancer
Medicine
Biomarker (medicine)
Combination therapy
DNA sequencing
DNA

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