A Rare Case of Isolated Adrenal Metastasis of Invasive Ductal Breast Carcinoma
2014
Introduction. Isolated adrenal metastases of invasive ductal breast carcinoma
are extremely rare. We report a case with isolated left adrenal metastases,
verified three years after diagnosed breast carcinoma. Case Outline. A
58-year-old female patient with a right breast tumor, clinically staged as
IIIA (T2N2M0) started neoadjuvant anthracycline chemotherapy after biopsy
which revealed invasive ductal breast carcinoma. Immunohistochemical findings
of tumor biopsy showed hormonal steroid receptors for estrogen and
progesterone negative, and human epidermal growth factor receptor 2 (HER2)
positive. After 4 cycles of chemotherapy and partial tumor regression the
patient underwent radical mastectomy. Definite histopathological analysis
confirmed the diagnosis of invasive ductal carcinoma. The patient continued
treatment with adjuvant chemotherapy to cumulative dose of anthracyclines,
postoperative radiotherapy and adjuvant trastuzumab for one year. Three years
later abdominal computerized tomography showed tumor in the left adrenal
gland as the only metastatic site. Left adrenalectomy was performed and
histopathological finding confirmed breast cancer metastases.
Postoperatively, the patient received 6 cycles of docetaxel with trastuzumab
and continued trastuzumab until disease progression. One year after left
adrenalectomy control abdominal computerized tomography showed a right
adrenal tumor with retroperitoneal lymphadenopathy. Treatment with
capecitabine was continued for one year, but eventually she developed brain
metastasis causing lethal outcome. Conclusion. In order to better understand
metastatic pathways of invasive ductal breast carcinoma, publications of
individual patient cases diagnosed with rare metastatic sites should be
encouraged. This might improve our understanding of metastatic behavior of
breast cancer and stimulate further clinical research.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
19
References
5
Citations
NaN
KQI