Catalytic Branching Cascades in Diversity Oriented Synthesis

Diversity-oriented synthesis (DOS) aims to generate small molecules with great structural diversity in an efficient manner. Recent years have witnessed significant achievements in the field, which helps to validate the usefulness of DOS as a tool for the discovery of novel, biologically interesting small molecules. Catalytic branching cascade strategy has emerged as a new strategy in DOS because of its potential to transform a common type of substrate into diverse and distinct molecular frameworks. The details of the concept has been presented herein.