Accumulation of genome-wide somatic loss of heterozygosity (LOH) as a prominent feature of advanced malignant soft tissue tumors and association with the BRCAness status, suppression of immune responses, and lower survival rates.

Katsuhito Takahashi,Yasutomo Miyaji,Ryotaro Ohkuma,Hajime Higuchi,Yoshihiro Komohara,Shinsuke Aida,Jun Yashima,Hiromasa Yamamoto,Ken Suzawa,Yuko Takahashi,Shinichi Toyooka,Hiroya Ashimine,Yu Oyama,Hiroyuki Narahara,Junko Yotsumoto,Hiroo Ishida,Takuya Tsunoda,Yasutsuna Sasaki,Yasuo Ono,Satoshi Teraoka

Accumulation of genome-wide somatic loss of heterozygosity (LOH) as a prominent feature of advanced malignant soft tissue tumors and association with the BRCAness status, suppression of immune responses, and lower survival rates.

2021

11533Background: Malignant soft tissue tumor is a rare cancer with few therapeutic options. Recent genomic analysis revealed widespread CNA and the cumulative burden of cancer-related pathogenic ge...

Keywords:

Loss of heterozygosity
Cancer research
Immune system
Medicine
Somatic cell
rare cancer
Malignant soft tissue tumors
Genome
Soft tissue
Feature (computer vision)

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