Human papillomavirus (HPV)–related head and neck squamous cell carcinoma (HNSCC) and outcome after treatment with epidermal growth factor receptor inhibitors (EGFR inhib) plus radiotherapy (RT) versus conventional chemotherapy (CT) plus RT.
2011
5528 Background: HPV-related HNSCC has been associated with an improved prognosis in patients treated with RT +/- CT; however, no information is available regarding patients treated with RT + EGFR inhib. Our purpose was to detect differences in outcome in patients treated with RT+EGFR inhib according to p16 tumor status. Methods: We retrospectively determined DNA of HPV 16 and immunohistochemical expression of p16 from formalin-fixed, paraffin-embedded (FFPE) tissue tumors from 78 patients with newly diagnosed locally advanced (LA)-HNSCC treated with RT + CT (37) and RT + EGFR inhib (41), entered in clinical trials. Tumors were classified dichotomously as either p16-positive (strong, diffuse staining) or negative, and DNA of HPV 16 was determined by multiplex polymerase chain reaction (PCR) methods. Disease free survival (DFS) and overall survival (OS) were analysed by Kaplan-Meyer method. Results: DNA of HPV 16 was found in 12 of 78 tumors (15%) and p16 positivity in 11 tumors (14%) with similar rates in...
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