Autoimmune hepatitis and juvenile systemic lupus erythematosus: 2 for 1?

Autoimmune hepatits (AIH) is characterized by increased liver enzymes, hypergammaglobulinemia, specific autoantibodies and typical hystologic findings. Extrahepatic autoimmune phenomena may coexist with type 1 AIH. Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease associated with the production of autoantibodies. Although it has the potential to affect any organ, clinically significant hepatic involvement is considered to be uncommon and liver dysfunction is not a diagnostic criteria.