2103-P: Sex Differences in Human Adipose Tissue: Comprehensive Transcriptome Profiling

The sexual dimorphism of adipose tissue is incompletely understood. Differences in total and regional adiposity have been described, but the molecular basis for these differences is unclear. We have conducted the first comprehensive transcriptome analysis in adipose tissue from healthy age and BMI-matched women and men. Results demonstrate upregulation of lipid and carbohydrate metabolism in pre and postmenopausal women vs. men. In men few genes were upregulated: the majority of these were related to inflammation vs. upregulation of inflammatory genes in men. Measurement of regional and intrahepatic fat, adipose cell size, and systemic insulin resistance complement RNAseq (n=39) and rtPCR (n=54) results. Disclosure G. Bogu: None. M. Snyder: Advisory Panel; Self; Jungla. Consultant; Self; Merck & Co., Inc. Other Relationship; Self; 10x Genomics, Akna, Filtricine, Illumina, Inc., January, Personalis, Qbio, SensOmics. T. McLaughlin: Advisory Panel; Self; January. Stock/Shareholder; Self; Eiger BioPharmaceuticals. Funding American Diabetes Association (1-11-CT-35 to T.M.); National Institute of Diabetes and Digestive and Kidney Diseases