The relationship between polymorphism of interleukin-6 and osteoprotgerin genes with dental peri-implant disease: A meta-analysis

Abstract Interleukin-6 (IL-6) and osteoprotegerin (OPG) are mediators involved in the regulating bone remodeling. Although the relation between the polymorphism of these mediators and dental peri-implant disease has been studied, contradictory results have been obtained. Therefore, meta-analysis has been used as a power tool to obtain comprehensive results on this path. In this review study, all articles with English abstracts were searched in the web of science, Embase, PubMed and Scopus databases up to February 2021. The searches have been carried out using the Medical Subject Heading (MESH) terms and free keywords. Amongst several studies, the heterogeneity percentage was evaluated by two measures named the Cochrane test and I2 statistic. The analyses were done by Comprehensive Meta-analysis v.2.0 software. Amongst the 8 articles obtained after the abstracts reviewing, 7 proper fitted articles were selected for meta-analysis. The combined odds ratio did not show a significant relationship between the polymorphism of IL-6 G174C gene and peri-implant disease. However, there was a significant relationship between polymorphism of OPG (rs2073618) gene and peri-implant disease susceptibility. Meta-analysis results showed that the CC genotype of OPG (rs2073618) increases the risk of pre-implant disease. But there was no significant relationship between polymorphism of IL-6 G174C and peri-implant disease. However, more studies with large sample sizes are needed to confirm these results. The discovery of genetic markers associated with peri-implant diseases may lead to strict patient selection and increase success in implant treatment.