The clinical value of detecting serum IgE and TNF-α in children with bronchial asthma

Objective To observe the clinical value of detecting tumor necrosis factor-α(TNF-α) and IgE contents in children with bronchial asthma.Methods The levels of serum IgE and TNF-α were measured in 32 children with bronchial asthma both during acute attack and after treatment(14 days later).28 normal healthy children were compared as controls.Results The levels of serum IgE and TNF-α in children with bronchial asthma during asthma attack were significantly higher than those in controls(P0.01).The levels of serum IgE and TNF-α in children with bronchial asthma treatment after 14 d further decreased than those in children with bronchial asthma during asthma attack(P0.01),but still remained higher than those of controls(P0.05).Significantly positive relationship was observed between IgE and TNF-α levels(r=0.597,P0.01).Conclusion The clinical detection of IgE and TNF-α levels are useful for assessment of the therapeutic efficacy.