Preparation of novel CaMoO4:Eu3+-MCM-41 nanocomposites and their applications and monitoring as drug release systems

Abstract Bortezomib loaded CaMoO4:Eu3+-MCM-41 nanocomposites were prepared and used in drug release studies. The surface of the synthesized mesoporous MCM-41 was functionalized with CaMoO4:Eu3+ with the gel obtained by Pechini sol-gel method. After calcination at 700 °C, CaMoO4:Eu3+-MCM-41 nanocomposites were obtained onto which Bortezomib was loaded via supercritical carbon dioxide technique at 200 bars and 40 °C. Structural characterization of MCM-41and the nanocomposites were made via XRD, FT-IR and Raman spectroscopies. Their particle sizes and morphologies were investigated by FE-SEM. The amount of drug loaded onto the nanocomposites was investigated by TG. Pore volumes were determined by N2 adsorption/desorption analysis. In vitro drug release studies were performed at 37 °C in SBF. The amount of drug released was determined via UV–vis spectrometric analysis. Luminescent properties and the release process were investigated by monitoring the changes in the luminescence intensity over time via photoluminescence spectrometer. MTT method was used for cell viability/toxicity studies.