Intratumoral T cell clonality and survival in a randomized phase II study of preoperative autophagy inhibition in combination with gemcitabine and nab-paclitaxel treatment in patients with resectable pancreatic cancer.

Pranav Murthy,Daniel Weber,Sagar N Sharma,Aatur D. Singhi,Nathan Bahary,Wenjing Pan,Miranda L. Byrne-Steele,Jian Han,Herbert J. Zeh,Tullia C. Bruno,Amer H. Zureikat,Michael T. Lotze

Intratumoral T cell clonality and survival in a randomized phase II study of preoperative autophagy inhibition in combination with gemcitabine and nab-paclitaxel treatment in patients with resectable pancreatic cancer.

2021

Pranav Murthy
Daniel Weber
Sagar N Sharma
Aatur D. Singhi
Nathan Bahary
Wenjing Pan
Miranda L. Byrne-Steele
Jian Han
Herbert J. Zeh
Tullia C. Bruno
Amer H. Zureikat
Michael T. Lotze

e16001Background: Autophagy is a cell survival mechanism that is upregulated in pancreatic ductal adenocarcinoma (PDAC). PDAC autophagy results in an altered metabolic phenotype that promotes tumor...

Keywords:

Gemcitabine
Medicine
Phases of clinical research
in patient
Nab-paclitaxel
Downregulation and upregulation
Resectable Pancreatic Cancer
Cancer research
Autophagy
T cell

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