C-Terminal lactamization of peptides
2021
Solid-phase synthesis of peptides with release through formation of C-terminal γ-, δ-, or e-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90 % yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
33
References
0
Citations
NaN
KQI