A systematic review of patients’ and providers’ perspectives of medications for treatment of opioid use disorder

Abstract Background The opioid epidemic is a public health crisis. Medications for opioid use disorder (MOUD) include: 1) buprenorphine, 2) methadone, and 3) extended-release naltrexone (XR-NTX). Research should investigate patients’ and providers’ perspectives of MOUD since they can influence prescription, retention, and recovery. Methods This systematic review focused on patients’ and providers’ perceptions of MOUD. The review eligibility criteria included inclusion of the outcome of interest, in English, and involving persons ≥ 18 years. A PubMed database search yielded 1692 results; we included 152 articles in the final review. Results There were 63 articles about buprenorphine, 115 articles about methadone, and 16 about naltrexone. Misinformation and stigma associated with MOUD were common patient themes. Providers reported lack of training and resources as barriers to MOUD. Conclusion This review suggests that patients have significant misinformation regarding MOUD. Due to the severity of the opioid epidemic, research must consider the effects of patients’ and providers’ perspectives on treatment for OUD, including the effects on the type of MOUD prescribed, patient retention and adherence, and ultimately the number of patients treated for OUD, which will aid in curbing the opioid epidemic.