P67 Characteristics and aetiology of non-CF bronchiectasis in east london children

Introduction Worldwide, non-cystic fibrosis bronchiectasis is a significant cause of morbidity and mortality, particularly in indigenous communities, and prevalence is higher than cystic fibrosis (CF). Despite this, research into non-CF bronchiectasis is limited. Often the aetiology is unknown and presumed to be secondary to a significant respiratory infection. We sought to characterise our cohort of non-CF bronchiectasis patients with regard to aetiology and disease progression. Method We identified children within our service with a radiological diagnosis of non-CF bronchiectasis through a retrospective review of patient notes. We excluded those with a confirmed diagnosis of primary ciliary dyskinesia Results We identified 15 children with non-CF bronchiectasis. Patient details are outlined in table 1. All patients except one had undergone a chest CT scan in the past 2 years (with the interval between scans being at least 2 years). All patients had stable image findings with no disease progression. One patient had resolution of bronchiectasis (secondary to inhaled peanut). Staph aureus was the most frequently encountered pathogen - reported in 40% [6] patients over the past year. Conclusion This is a limited data set but highlights some areas of note worth further exploration. The aetiology was varied but a significant proportion had historical aspiration or infantile respiratory infection. It is therefore worth considering aspiration as a potential aetiology in these patients. 33% of patients had been admitted to hospital over the past year and FEV1 was quite varied implying a spectrum of disease severity. There was no evidence of radiological disease progression suggesting that disease stability with appropriate management is possible.